The Effectiveness of Mobile Phone Text Messages on the Adherence of Antiretroviral Drug Taking in Patients Living with HIV/AIDS: A Meta-Analysis


  • Fara Aristya Prisma Master's Program of Public Health, Universitas Sebelas Maret, Indonesia
  • Hanung Prasetya Study Program of Acupuncture, School of Health Polytechnics, Ministry of Health Surakarta, Indonesia
  • Burhannudin Ichsan Faculty of Medicine, Universitas Muhammadiyah Surakarta, Indonesia



Background: The use of ARV therapy has been shown to reduce the mortality and morbidity of PLHIV. The characteristic factor of the PLHIV health care system is a key factor as well as how health workers and services synergize to improve patient adherence to adherence to taking ARVs.

Subjects and Method: This research was conducted using a systematic review and meta-analysis with PICO namely, Population: PLHIV. Intervention; mobile phone text message. Comparison: not given a mobile phone text message. Outcome: obediently taking ARVs. By searching articles in 4 databases namely PubMed, Google Scholar, Science Direct, and ProQuest published from 2012 to 2022, entering the following keywords (“Mobile phone text messages” OR mHealth) AND antiretroviral AND (HIV or AIDS) AND “Randomized controlled trials”. Articles were selected using PRISMA flow and data analysis using the Review Manager 5.3 application.

Results: There are a total of 9 articles using the RCT study design with a total sample of 2,762 PLHIV from China, Estonia, Nigeria, Cameroon, Kenya, and Mozambique which have been subject to systematic review and meta-analysis. The data that has been processed shows that mobile phone text messages are effective in increasing PLWHA adherence in taking ARVs, and are statistically close to significant. PLHIV who receive mobile phone text messages are more likely to comply with taking ARVs 1.12 times than those who do not receive mobile phone text messages (RR= 1.12; 95% CI= 1.00 to 1.26; p= 0.050).

Conclusion: Mobile phone text messages are effective in increasing PLWHA compliance in taking ARVs.

Keywords: HIV/AIDS, ODHA, ARV, mobile phone text messages.


Fara Aristya Prisma, Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta, Central Java 57126. Email: Mobile: +6285697129819.


Belzer ME, MacDonell KK, Ghosh S, Naar S, McAvoy-Banerjea J, Gurung S, Cain D, Fan CA, Parsons JT. (2018). Adaptive antiretroviral therapy adhe¬rence interventions for youth living with HIV through text message and cell phone support with and without incentives: protocol for a sequential multiple assignment randomized trial (SMART). JMIR Res. Protoc. 7(12): 98-114. Doi: 10.2196/-11183.

Kemenkes RI. (2021). Buku hari AIDS sedunia (World AIDS day book). Direktorat Jenderal Pencegahan dan Pengendalian Penyakit. Jakarta: Kementrian Kesehatan Republik Indonesia.

Kemenkes RI. (2022). Profil kesehatan republik Indonesia tahun 2021 (Health profile of the Republic of Indonesia in 2021). Kementrian Kesehatan Repubik Indonesia.

Maduka O, Obin-West CI. (2013). Adherence counseling and reminder text messages improve uptake of antiretroviral therapy in a tertiary hospital in Nigeria. Niger. J. Clin. Prac. 16(3): 302–308. Doi: 10.4103/1119-3077.-113451

Fairbanks J, Beima-Sofie K, Akinyi P, Matemo D, Unger JA, Kinuthia J, O’Malley G, Drake AL, John-Stewart G, Ronen K. (2018). You will know that despite being HIV positive you are not alone: Qualitative study to inform the content of a text messaging intervention to improve prevention of mother-to-child HIV transmission. JM¬IR Mhealth Uhealth, 6(7): 112-124.Doi: 10.2196/10671

Liu, AY, Vittinghoff E, Von FP, Rivet AK, Anderson PL, Lester R, Andrew E, et al. (2019). Randomized controlled trial of a mo-bile health intervention to promote retention and adherence to preexpo-sure prophylaxis among young people at risk for human immunodeficiency virus: the EPIC study. Arch. Clin. Infect. Dis. 68(12): 2010–2017. Doi: 10.1093/cid/ciy810.

Mbuagbaw L, Thabane L, Ongolo-Zogo P, Lester RT, Mills EJ, Smieja M, Dolo-vich L, Kouanfack C. (2012). The Cameroon mobile phone SMS (CAM-PS) trial: a randomized trial of text messaging versus usual care for adherence to antiretroviral therapy. PLoS One. 7(12): 6–12. Doi: 10.1371/journal.pone.0046909.

Nhavoto JA, Grönlund Å, Klein GO. (2017). Mobile health treatment support intervention for HIV and tuberculosis in Mozambique: Perspectives of patients and healthcare workers. PLoS One. 12(4): 1–13. Doi: 10.1371/ journal.pone.0176051

Nindiyastuti NAI, Prasetya H, Murti B. (2018). Determinants of mobile voluntary counselling and testing of HIV use among gay in Surakarta, Central Java. J. Health Promotion Behavior. 3(3): 155–165. Doi: 10.-26911/thejhpb.2018.03.03.03.

Patel AR, Kessler J, Braithwaite RS, Nucifora KA, Thirumurthy H, Zhou Q, Lester RT, Marra CA. (2017). Economic evaluation of mobile phone text message interventions to improve adherence to HIV therapy in Kenya. Am. J. Med. 96(7): 1–9. Doi: 10.1097/MD.0000000000006078.

Sabin LL, DeSilva MB, Gill CJ, Li Z, Vian T. (2015). Improving adherence to anti-ret¬roviral therapy with triggered real time text message reminders: the China through technology study (CATS). J. Acquir. Immune. Defic. Syndr. 69(5): 551-559. Doi: 10.1097/QAI.000000000000000000651.

Srikartika VM, Intannia D, Aulia R. (2019). Faktor-faktor yang mempengaruhi kepatuhan pasien HIV/AIDS rawat jalan dalam pengobatan terapi antiretroviral (ART) di Rumah Sakit Dr. H. Moch. Ansari Saleh Banjarmasin (Factors influencing adherence of out-patient HIV/AIDS patients to antiretroviral therapy (ART) at Dr. H. Moch. Ansari Saleh Hospital, Banjarmasin). J. farm. sains praktis. 6(1): 97. Doi: 10.20527/jps.v6i1.6081.

Yé M, Kagoné M, Sié A, Bagagnan C, Sanou H, Millogo O, Duclos V, Tinto I, Bibeau G. (2018). Promoting access equity and improving health care for women, children and people living with HIV/AIDS in Burkina Faso through mHealth. J. Public Health (Oxf). 40: II42–II51. Doi: 10.1093/pubmed/-fdy196.

WHO (2022). Key Fact: Global data HIV/AIDS. health-topics/hiv-aids#tab=tab_1. Diakses pada tanggal 3 September 2021.




How to Cite

Prisma, F. A., Prasetya, H., & Ichsan, B. (2023). The Effectiveness of Mobile Phone Text Messages on the Adherence of Antiretroviral Drug Taking in Patients Living with HIV/AIDS: A Meta-Analysis. Journal of Health Promotion and Behavior, 8(3), 195–205.




Most read articles by the same author(s)

1 2 3 4 > >>