Meta-analysis Effect of Compliance with Folic Acid Supplement Consumption in Pregnant Women on the Risk of Birth Defects

Authors

  • Fathia Mutiara Zahra Study Program of Pharmacy, Universitas Sebelas Maret
  • Frannesty Estu Winahyu Study Program of Acupuncture, Health Polytechnic, Ministry of Health Surakarta
  • Bhisma Murti Masters Program in Public Health, Universitas Sebelas Maret

Abstract

Background: Low concentrations of folic acid supplement intake during pregnancy can cause birth defects in the baby. Therefore, this study was conducted to identify those associated with adherence to folic acid supplement consumption in pregnant women and provide a shadow for further research. The purpose of this study was to investigate the effect of birth defects and pregnant women's adherence to taking folic acid supplements during pregnancy.

Subjects and Method: This study uses the PRISMA flowchart to perform the meta-analysis. The article review process took place between 2017 and 2022 with PICO as follows, Population: Pregnant Women. Intervention: Folic acid consumption before and during pregnancy, Comparison: no folic acid consumption before and during pregnancy, Outcome: risk of birth defects, articles collected using databases such as PubMed, Google Scholar, and Science Direct used. The articles obtained will be filtered using the stages according to the PRISM flow diagram. The analysis was carried out using RevMan 5.3.

Results: A total of 9 articles, including 6 articles from the Asian continent, namely China, Japan, India, and Bangladesh, 2 articles from the Americas, namely Mexico and New York, and 1 from the African continent, namely Ethiopia. Wherefrom the meta-analysis of 9 articles, it is known that adherence to folic acid supplementation can reduce the risk of birth defects in pregnant women (aOR= 0.69; 95% CI= 0.50 to 0.96; p= 0.003).

Conclusion: Adherence to folic acid supplementation can help reduce the risk of birth defects in pregnant women.

Keywords: pregnant women, folic acid, birth defects.

Correspondence:

Fathia Mutiara Zahra. Study Program of Pharmacy, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: efemzahra31@student.uns.ac.id. Mobile: +62815-67987661.

Journal of Health Promotion and Behavior (2022), 07(02): 97-107
DOI: https://doi.org/10.26911/thejhpb.2021.07.02.02

References

Atlaw Daniel, Ayanaw Worku, Molla Taye, Demelash Woldeyehonis and Abebe Much (2019). Neural Tube Defect and Associated Factors in Bale Zone Hospitals, Southeast Ethiopia. J Preg Child Health. http://dx.doi.org/10.4172/2376-127X.1000412.

Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, Epling JW, Jr Gar-cia FA, Tseng CW (2017). Folic acid supplementation for the prevention of neural tube defects: US preventive services task force (USPSTF) recommendation statement. JAMA. 317(2): 183–189. DOI: 10.1001/jama.2016.19438

Critical Appraisal Skills Programme (CASP) part of Oxford Centre for Triple Value Healthcare Ltd. (2018). www.casp-uk.net visit: http://creativecom mons.org/licenses/byncsa/3.0/

Ito Kumiko, Tomoyuki Hanaoka, Naomi Tamura, Seiko Sasaki, Chihiro Miyas-hita, Atsuko Araki, Sachiko Ito, et al. (2019). Association Between Maternal Serum Folate Concentrations in the First Trimester and the Risk of Birth Defects: The Hokkaido Study of Environment and Children’s Health. DOI: 10.2188/jea.JE20170185

Kancherla Vijaya, Md Omar Sharif Ibne Hasan, Rezina Hamid, Ligi Paul, Jacob Selhub, et al,. (2017). Prenatal folic acid use associated with decreased risk of myelomeningocele: A case-control study offers further support for folic acid fortification in Bangladesh. DOI: 10.1371/journal.pone.0188726

Liu J, Li Z, Greene NDE, Li H, Ren A. (2017). The recurrence risk of neural tube defects (NTDs) in a population with high prevalence of NTDs in northern China. Oncotarget, 8(42), 72577–72583. DOI: 10.18632/onco-target.19890

Liu J, Li Z, Ye R, Ren A, Liu J (2019). Folic acid supplementation and risk for congenital limb reduction defects in China. Int J Epidemiol. 48(6): 2010-2017. https://doi.org/10.1093/ije/dy-z130.

Mao Baohong, Jie Qiu, Nan Zhao, Yawen Shao, Wei Dai, Xiaochun He, Hongmei Cui, et al. (2017). Maternal folic acid supplementation and dietary folate intake and congenital heart defects. PLoS One. 12(11):e0187996. https://doi.org/10.1371/journal.pone.0187996.

Mendonca Vivienne J BDS MD MPH (2019). Maternal Folic Acid Intake and Risk of Nonsyndromic Orofacial Clefts: A Hospital-Based Case–Control Study in Bangalore, India. Cleft Palate Craniofac J. 57(6):678-686. https://doi.org/10.1177/1055665619893214.

Petersen JM, Parker SE, Benedum CM, Mitchel AA, Tinker SC, Werler MM (2019). Periconceptional folic acid and risk for neural tube defects among higher risk pregnancies. Birth Defects Res. 111(19):1501-1512. https://doi.org/10.1002/bdr2.1579.

Qu P (2019). Propensity-matched study of the association between optimal folic acid supplementation and birth defects in Shaanxi province, Northwestern China. Sci Rep. 9: 5271. https://doi.org/10.1038/s41598-019-41584-5.

Corona-Rivera JR, Bobadilla-Morales L, Corona-Rivera A, Peña-Padilla C, Olvera-Molina S, Orozco-Martín MA, García-Cruz D, et al. (2018). Prevalence of orofacial clefts and risks for nonsyndromic cleft lip with or without cleft palate in newborns at a university hospital from West Mexico. Congenit Anom (Kyoto). 58(4): 117-123. https://doi.org/10.1111/cga.12276.

WHO (2012). Daily Iron and Folic Acid Supplementation in Pregnant Wo¬men. Geneva World Health Organization.

Yoshida S, Takeuchi M, Kawakami C, Kaw-akami K, Ito S (2020). Maternal multivitamin intake and orofacial clefts in offspring: Japan Environtment and Children’s Study (JECS) cohort study. bmj Open. 10(3). http://dx.doi.org/10.1136/bmjopen-2019-035817.

Downloads

Published

2022-04-18

How to Cite

Zahra, F. M., Winahyu, F. E., & Murti, B. (2022). Meta-analysis Effect of Compliance with Folic Acid Supplement Consumption in Pregnant Women on the Risk of Birth Defects. Journal of Health Promotion and Behavior, 7(2), 97–107. Retrieved from https://thejhpb.com/index.php/thejhpb/article/view/359

Issue

Section

Articles

Most read articles by the same author(s)

1 2 3 4 5 6 7 8 9 > >>