Meta-Analysis: The Effect of Social Support on Medication Treatment Adherence in Tuberculosis Patients


  • Lily Nabillah Masters Program in Public Health, Universitas Sebelas Maret
  • Argyo Demartoto Faculty of Social and Political Sciences, Universitas Sebelas Maret
  • Bhisma Murti Masters Program in Public Health, Universitas Sebelas Maret


Background: Tuberculosis is a disease that can be cured by various methods of treatment. How­ever, tuberculosis treatment is often not carried out properly and completely. The importance of medication adherence as a top priority in the effectiveness of treatment of tuberculosis patients through social support. The purpose of this study was to analyze the effect of social support on medication adherence in tuberculosis patients.

Subjects and Method: This meta-analysis study used the PRISMA flowchart guideline with PICO, Population= Tuberculosis patients. Intervention= social support. Comparison= without social support. Outcome= medication adherence. The search process was carried out between 2017 and 2022 using Google Scholar, PubMed, Sci-Hub, and Science Direct databases. The keywords used were "Medication Adherence" OR "Drug Adherence" OR "Adherence" OR " treatment adhe­rence" AND "Tuberculosis" OR "multidrug resistant tuberculosis*" OR "Mycobacterium tuber­culosis Infection" AND "Social Support" OR "Social Support System" OR "Psychosocial Support System" OR "Support System". Based on the database, there are 10 articles that fulfill the inclusion criteria. Study analysis was using review manager 5.3 software.

Results: There were 10 articles from the continents of Asia and Africa selected in this meta-analysis, the results showed that the presence of social support has the possibility to increase adherence to anti-tuberculosis treatment compared to without social support in tuberculosis patients and it was statistically significant (aOR= 2.10; CI 95%= 1.76 to 2.52; p< 0.001).

Conclusion: Tuberculosis patients who have strong social support about tuberculosis adherence are more likely to adhere to anti-tuberculosis treatment.

Keywords: tuberculosis, social support, medication adherence, meta-analysis.


Lily Nabillah. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Mobile: +62 821-1135-6435.

Journal of Health Promotion and Behavior (2022), 07(03): 250-261


Ajema D, Shibru T, Endalew T, Gebeyehu S (2020). Level of and associated factors for non-adherence to anti-tuberculosis treatment among tuberculosis patients in Gamo Gofa zone, Southern Ethiopia: cross-sectional study. BMC Public Health, 20(1): 1–9. doi: 10.1186/s12889-020-09827-7.

Arifin VN, Juariah, Nur A, Uzair FM (2019). The relationship of social support with medication adherence pulmonary tuberculosis patients through DOTS strategy in Pidie Aceh Indonesia, IOP Conference series: Materials science and engineering, 469(1). doi: 10.1088/1757-899X/469/1/012055.

Barendregt JJ, Doi SA, Lee YY, Norman RE, Vos T (2013). Meta-analysis of prevalence. J.Epidemiol Community Health, 67(11): 974–978. doi: 10.1136/jech-2013-203104.

Barik AL, Indarwati R, Sulistiawati S (2020). The role of social support on treatment adherence in tb patients: a systematic review, Nurse and health: Jurnal keperawatan, 9(2): 201–210. doi: 10.36720/nhjk.v9i2.186.

CEBM (2014). Critical appraisal of a cross-sectional study (survey) appraisal questions, p. 1. Available at: july-2014.pdf.

Charyeva Z, Curtis S, Mullen S, Senik T, Zaliznyak O (2019). What works best for ensuring treatment adherence. Lessons from a social support program for people treated for tuberculosis in Ukraine, PLoS one, 14(8): 1–13. DOI: 10.1371/journal.pone.0221688.

Deshmukh RD, Dhande DJ, Sachdeva KS, Sreenivas AN, Kumar AMV, Parmar M (2018) Social support a key factor for adherence to multidrug-resistant tuberculosis treatment, Indian J Tuber, 65(1). doi: 10.1016/j.ijtb.2017.-05.003.

Duko B,Bedaso A, Ayano G,Yohannis Z (2019). Perceived stigma and associated factors among patient with tuberculosis, Wolaita Sodo, Ethiopia: Cross-sectional study, Tuber Res Treat, page. 1–5. DOI: 10.1155/2019/-5917537.

Field AP, Gillett R (2010). How to do a meta-analysis. Br. J. Math. Stat. Psychol, 63(3):665–694. doi: 10.1348/000711010X502733.

Gashu KD, Gelaye KA, Tilahun B (2021). Adherence to tb treatment remains low during continuation phase among adult patients in Northwest Ethiopia. BMC Infect. Dis, 21(1):

Hoorn RV, Jaramillo E, Collins D, Hebhard A, Hof SVD (2016). The effects of psycho-emotional and socio-economic support for tuberculosis patients on treatment adherence and treatment outcomes – a systematic review and meta-analysis, PLoS ONE, 11(4). doi:

Irianti TT, Kuswandi K (2016) Mengenal Anti-Tuberkulosis (Knowing Anti-Tuberculosis). Yogyakarta: Grafika Indah.

Irnawati NM, Siagian IET, Ottay RI (2016). Pengaruh dukungan keluarga terhadap kepatuhan minum obat pada penderita tuberkulosis di puskesmas Motoboi Kecil Kota Kotamobagu (The effect of family support on medication adherence in tuberculosis patients at the Motoboi Kecil Health Center, Kotamobagu City). Jurnal Kedokteran Komunitas Dan Tropik. 4(1).

Li X, Wang B, TAn D, Li M, Zhang D, Tang C, Cai X, et al. (2018). Effectiveness of comprehensive social support interventions among elderly patients with tuberculosis in communities in China: A community-based trial. J.Epidemiol Community Health, 72(5): 369–375. doi: 10.1136/jech-2017-209458.

Mando NJ, Widod D, Sutriningsih A (2018). Hubungan dukungan keluarga dengan kepatuhan minum obat pada pasien tb di puskesmas Janti Kota Malang (Relationship between family support and medication adherence in TB patients at the Janti Public Health Center, Malang City). Nursing News: Jurnal Ilmiah Keperawatan, 3(3):550–556.

Mengesha MM, Gebremichael MA, Watumo D, Hallström IK, Jerene D (2022). Poor adult tuberculosis treatment outcome and associated factors in Gibe Woreda, Southern Ethiopia: An institution-based cross-sectional study. PLOS glob. public health, 2(3), p. e0000161. doi: 10.1371/journal.-pgph.0000161.

Mohammedhussein M, Hajure M, Shifa JE, Hassen TA (2020). Perceived stigma among patient with pulmonary tuberculosis at public health facilities in southwest Ethiopia: A cross-sectional study. PLoS ONE, 15(12 December): 1–11. DOI: 10.1371/journal.pone.-0243433.

Muna L, Soleha U (2018). Motivasi dan dukungan sosial keluarga mempengaruhi kepatuhan berobat pada pasien tb paru di poli paru Bp4 Pame-kasan (Family motivation and social support affect medication adherence in pulmonary tuberculosis patients at the pulmonary outpatient clinic Bp4 Pamekasan). J. Health Sci, 7(2): 172–179. doi: 10.33086/jhs.v7i2.506

Saqib SE, Ahmad MM, Panezai S (2019). Care and social support from family and community in patients with pulmonary tuberculosis in Pakistan, Fam. Med. Community Health., 7(4): 1–9. doi: 10.1136/fmch-2019-000121.

Siregar FA, Andayani LS (2020). Analysis social determinant of adherence to treatment in pulmonary tuberculosis patients in Medan City, (Icosteerr 2018): 942–945. doi: 10.5220/0010-104709420945.

Taylor S (2009). Health psychology (7th ed). in. Boston: McGraw-Hill

Tola HH (2017). The effect of psychosocial factors and patient perception of tuberculosis treatment non-adherence in Addis Ababa, Ethiopia. J. Health Sci, 27(5: 447–458. doi: 10.4314/ejhs.v27i5.2.

Widiyanto A, Murti B, Soemanto RB (2018). Multilevel Analysis on The Effect of Socio-Cultural, Lifestyle factors, and School Environment, on the Risk of Overweight in Adolescents, Karang-anyar District, Central Java. J. Epidemiol. Public Health. 3(1): 94-104. DOI: 10.26911/jepublic-health.2018.03.01.08




How to Cite

Nabillah, L., Demartoto, A., & Murti, B. (2022). Meta-Analysis: The Effect of Social Support on Medication Treatment Adherence in Tuberculosis Patients. Journal of Health Promotion and Behavior, 7(3), 250–261. Retrieved from




Most read articles by the same author(s)

1 2 3 4 5 6 7 8 9 10 > >>